The ADNI database includes item level data, thereby allowing for calculation of a total score and index scores. We used the scores from participants’ first administration of the MoCA during their baseline study visit. Finally, participants with AD have a memory complaint or memory problem noted by their study partner, an education-adjusted cutoff score on Logical Memory delayed recall, a MMSE score between 20 and 26, a CDR score between 0.5 and 1.0, and meet NINCDS/ADRDA criteria for probable AD. MCI subjects have a memory complaint or a memory problem noted by their partner, a specified education-adjusted cutoff score on Logical Memory, a MMSE score between 24 and 30, a CDR score (including the Memory Box score) of 0.5, and relatively preserved IADL. Based upon performance guidelines in the ADNI protocol, controls are defined as having no significant memory complaints beyond those expected for age, a specified education-adjusted cutoff score on Logical Memory delayed recall, a MMSE score between 24 and 30 points, a CDR score of 0 (including a 0 on the Memory Box score), and intact instrumental activities of daily living (IADL). ĭiagnosis of cognitively intact, amnestic MCI, or AD in ADNI is based on a cognitive screening battery that includes the Mini-Mental State Examination (MMSE), immediate and delayed recall of the first Logical Memory story (Anna Thompson) from the Wechsler Memory Scale-Revised, and the Clinical Dementia Rating (CDR) interview conducted with each subject and their program partner. Additional inclusion/exclusion criteria are available at. Inclusion criteria for ADNI require an age range between 55 and 90 years, a minimum of 6 years of formal education, fluency in English or Spanish, Hachinski Ischemic Scale scores ≤4 points (out of a possible 18), and Geriatric Depression Scale Short Form scores 2 doses per week).
Moca score interpretation ranges serial#
The primary goal of ADNI has been to test whether serial magnetic resonance imaging, positron emission tomography, other biological markers, and clinical and neuropsychological assessment can be combined to measure the progression of MCI and early AD. The ADNI was launched in 2003 as a public-private partnership, led by the principal investigator Michael W. reported that with the exception of the Language Index Score (AUC = 0.58), the AUCs of the other index scores (range = 0.61–0.63) were also significant predictors of conversion from MCI to AD.ĭata used in the preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database ( ). While not as strong as the Memory Index (area under the curve = 0.66) in predicting conver sion to AD, Julaynont et al. Conversion to AD was 90.5% in patients with scores below the cutoff for impairment on both the total score (< 20/30 points) and the Memory Index Score (< 7/15 points), 74.5% when 1 score was below the cutoff, and 53% when both scores were above the cutoff. The investigators found that both the traditional total score and the Memory Index Score, consisting of the performance on delayed free, cued, and recognition conditions of the word list, were strong predictors of conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD) over an average follow-up of 18 months. developed MoCA index scores for the domains of memory, executive function, visuospatial function, language, attention, and orientation. Traditional interpretation of the MoCA is based upon the summed points across all items, with a maximum of 30 points. The Montreal Cognitive Assessment (MoCA) is a popular test used for cognitive screening in dementia clinics. A combined score has stronger incremental validity than the individual index scores. Conclusion: Administration of the entire MoCA is more informative than the index scores, especially in distinguishing normal cognition versus MCI. A combined score incorporating the Memory, Executive, and Orientation indexes also improved incremental validity for all 3 group comparisons. Results: Effect sizes for the total score were large (> 0.80) and exceeded the index scores in differentiating those with MCI versus normal cognition, MCI versus AD, and AD versus normal cognition. Methods: Effect sizes were calculated for Alzheimer’s Disease Neuroimaging Initiative research participants with normal cognition ( n = 295), MCI ( n = 471), or AD ( n = 150). Background/Aims: The aim of this paper was to evaluate the incremental validity of the Montreal Cognitive Assessment (MoCA) index scores and the MoCA total score in differentiating individuals with normal cognition versus mild cognitive impairment (MCI) or Alzheimer disease (AD).
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